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KMID : 0374920150360010007
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Inje Medical Journal
2015 Volume.36 No. 1 p.7 ~ p.15
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The Effect of Fluconazole Prophylaxis in Preterm Infant less than 28 weeks
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Baek Chung-Lyul
Lee Hyon-Hui
Jung Ji-Mi
Chung Mi-Lim
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Abstract
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Objective: Neonatal candida sepsis is an important cause of morbidity and mortality in preterm infants. The purpose of the this study was to evaluate the effect of fluconazole prophylaxis in preterm infant less than 28 weeks.
Methods and Materials: From January 2013 to June 2015, 30 preterm infants less than 28 weeks who were admitted to the Neonatal Intensive Care Unit of Haeundae Paik Hospital were chosen at random. We were divided into three groups; Group A (low dose fluconazole group, at dose of 3mg per kilogram of body weight), Group B (high dose fluconazole group, at dose of 6mg per kilogram of body weight), and Group C (non-fluconazole group). We were compared the incidence of candida sepsis and clinical characteristics in each group.
Results: Gestational age, birth weight, sex, mode of delivery, mother age and apgar score were similar in each group. Also, there was no difference of risk factors of candida sepsis such as duration of umbilical catheter in each group. The incidence of candida sepsis was 0% in the Group B, and 40% in the Group C. And this was statistically significant(p<0.05). There was no evidence of hepatobiliary toxicity of prophylactic fluconazole.
Conclusion: The administration of prophylactic fluconazole in preterm infants less than 28 weeks was effective in preventing candida sepsis without significant adverse effects.
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KEYWORD
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Fluconazole, Preterm infant, Candida sepsis, Prophylaxis
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